Human Genomics and Genomic Medicine

Epigenetics Biomarkers

Epigenetic biomarkers are emerging as powerful tools for screening, early disease detection, prognosis, treatment monitoring, and predicting the risk of future disease development. In cancer, significant alterations in the epigenetic landscape play a key role in the onset and progression of malignancies. These changes include widespread DNA methylation modifications across the genome, along with shifts in post-translational histone modifications.

Such epigenetic disruptions affect multiple stages of tumor development, ultimately driving the selection and expansion of cancer cells with enhanced pathogenic potential. As our understanding of these mechanisms grows, epigenetic biomarkers are proving to be valuable assets in advancing personalized medicine and improving clinical outcomes.